What Are The Side Effects Of Metronidazole And Fluconazole
Metronidazole side effects
Flagyl is a useful antibiotic and is generally well tolerated with appropriate use.
The most common and minor side effects include:
Side effects that are uncomfortable, but may become serious include:
Serious side effects of Flagyl are rare and the drug should be stopped if these symptoms appear:
- Colon cancer in people with Crohn’s disease
Fluconazole side effects
- reduced number of white blood cells,
- reduced number of blood platelets, and
- toxic epidermal necrolysis.
Rarely, serious allergic reactions, including angioedema , may also occur. Liver dysfunction and abnormal heartbeats have been associated with fluconazole. Stevens-Johnson syndrome has also been reported.
Dosage For Cryptococcal Meningitis
Adult dosage
- Typical dosage: 400 mg on the first day. The dose from day 2 on is usually 200400 mg, taken once per day.
- Treatment length: Treatment typically lasts 1012 weeks after a test called a cerebrospinal fluid culture no longer detects fungi.
Child dosage
Dosage for children is based on weight.
- Typical dosage: On the first day, your child will take 12 mg per kilogram of body weight. The dose from day 2 on is usually 612 mg per kilogram, taken once per day.
- Treatment length: Treatment typically lasts 1012 weeks after a test called a cerebrospinal fluid culture no longer detects fungi.
Child dosage
Use of this drug isnt recommended in infants younger than 6 months.
Senior dosage
The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects. Your doctor may start you on a lowered dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.
How Should I Use This Medication
The recommended dose of fluconazole for vaginal candidiasis infections is a single 150 mg dose.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is very important that this medication be taken as suggested by your doctor or pharmacist.
Store this medication at room temperature and keep it out of the reach of children.
Do not dispose of medications in wastewater or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
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Fluconazole Yeast Infection: Uses Dosages Side Effects And More
- Oyewale Oyelami
Fluconazole is an antifungal drug used to treat different kinds of fungus. The most common fungus is caused by a yeast called candida, which can lead to infections including:
- Balanitis thrush
- Blood infections
Fluconazole belongs to the group of drugs called triazole antifungals and came into public use in 1988. Available as a generic medication, it is on the WHOs List of Essential Medications.
While fluconazole yeast infection treatment is the most common medication, healthcare providers also prescribe it as a preventative measure for high-risk patients like organ transplant recipients and low birthweight babies to avoid fungal infections.
A doctor usually prescribes Fluconazole. However, you can only get it with a prescription in the UK, EU, Australia, and the USA.
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Fluconazole May Interact With Other Medications
Fluconazole oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs youre taking. To find out how this drug might interact with something else youre taking, talk with your doctor or pharmacist.
Examples of drugs that can cause interactions with fluconazole are listed below.
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Warnings For Other Groups
Pregnant women: Research in humans has shown adverse effects to the fetus when the mother takes this drug in doses of 150 mg or higher. In lower doses, research in animals has shown adverse effects. There havent been enough studies done to be certain how lower doses of the drug might affect the human fetus.
This drug should only be used during pregnancy in serious cases where its needed to treat a dangerous infection in the mother. And it should only be used if the potential risk to the fetus is acceptable given the drugs potential benefit.
Talk with your doctor if youre pregnant or planning to become pregnant. Ask your doctor to tell you about the specific harm that may be done to the fetus.
If you become pregnant while taking this drug, call your doctor right away.
Women who are breastfeeding: Fluconazole passes into breast milk and may cause side effects in a child who is breastfed. Talk with your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this drug.
For seniors: The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.
For children: This medication shouldnt be used in people younger than 6 months.
What Is Metronidazole What Is Fluconazole
Metronidazole is an antibiotic used to treat bacterial vaginosis, trichomonas vaginal infections, carriers of trichomonas who do not have symptoms of infection, Giardia infections of the small intestine, amebic liverabscess, amebic dysentery , abscesses , acne rosacea, and metronidazole vaginal gel is used to treat bacterial vaginosis.
Fluconazole is an antifungal medication used for treating vaginal, oral, and esophageal fungal infections caused by Candida. Diflucan also may be effective in treating urinary tract infections, peritonitis, pneumonia, and disseminated infections caused by Candida. Diflucan is also used for treating cryptococcal meningitis, and prevention of Candida infections in patients treated with chemotherapy or radiation after bone marrow transplantation.
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Meningitis Due To Candida Sp
Very few data exist on fluconazoleâs efficacy for the initial treatment of Candida sp. meningitis in adults, although this drug has a very good CSF penetration. Oral fluconazole was successful for the treatment of a C. albicans meningitis in an HIV-infected patient with a CD4 cell count of 35 cells/mm3 who refused intravenous therapy.
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How Does This Medication Work What Will It Do For Me
Fluconazole 150 mg capsules are an antifungal medication used to treat vaginal yeast infections caused by the yeast known as Candida. It works by stopping the growth of Candida. It usually starts to work within one day, but it may take 3 days for your symptoms to improve and up to 7 days for your symptoms to disappear.
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
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Dose Regime For Oral Fluconazole
For vulvovaginal candidiasis, a single oral dose of fluconazole 150 mg is usually effective. It can be repeated.
For dermatophyte infections and pityriasis versicolor, either 50 mg daily or 150 mg once weekly is taken for two to six weeks.
Once-weekly fluconazole is often used off-label to treat toenail fungal infections .
Larger doses are required for systemic infections.
Fluconazole is not normally used in children but doses of 5 mg/kg/day have been safely prescribed for a serious infection.
Fluconazole Dosage For Vaginal Candidiasis
Vaginal candidiasis is one of the most common uses for fluconazole. In patients with uncomplicated disease , a one-day treatment is sufficient. Patients with complicated disease may require longer therapy, typically fluconazole every three days for three doses. Recurrent disease requires weekly fluconazole for six months. Finally, pregnant patients should not use oral fluconazole due to its potential for harm to the fetus. Rather, a seven-day course of intravaginal therapy should be used.
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How To Take Fluconazole
Fluconazole is available as a capsule or liquid is taken by swallowing. It can also be given by injection, although this is typically only done in a hospital setting.
Make sure to read the patient information leaflet given to you by the pharmacist with your medication. Then, reach out to your doctor or pharmacist if you have any questions.
Fluconazole is usually taken by mouth once a day to treat candida infections. The medication is absorbed almost entirely within two hours, and its absorption isnt affected by the presence of stomach acid therefore, you can take it with or without food.
If you take the oral suspension form of Fluconazole, shake it well before using it. Then, carefully measure out the dosage with a proper measuring spoon. A regular household spoon may not give you the correct dose.
Maintaining a constant level of the medication in your body leads to the best results, so make sure you take the full prescribed dose simultaneously every day. Do not stop taking the drug if you find your symptoms lessen or disappear before youve finished the full prescription amount, as stopping early can allow the fungus to recover and grow.
Fluconazole Dosage For Esophageal And Oropharyngeal Candidiasis
Fluconazole is commonly used to treat yeast infections of the mouth or throat . The typical dose is 50 to 200 mg on day one, followed by 50 to 400 mg depending on whether the infection is in the mouth , just behind the mouth , or lower in the esophagus . Yeast infections of the throat typically resolve within several days, but treatment should be continued for two to three weeks, .
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Peritonitis Due To Candida Sp
Peritonitis due to Candida sp. may develop in patients with peritoneal dialysis catheters, or in those with surgical or traumatic injury to the gut wall. In this latter situation, Candida spp. are usually part of a polymicrobial infection. Isolation of Candida by direct examination of peritoneal fluid is an independent factor for a severe outcome, and recent small studies suggest that prompt, effective, adequate and safe antifungal therapy should be given in all cases of Candida sp. peritonitis in order to lower the mortality rate and shorten the hospital stay., In a recent study of 23 cases secondary to peptic ulcer perforation, the mortality rate in patients receiving fluconazole was high , probably related to inadequate or too late initiation of antifungal therapy. Some cases showing fluconazole efficacy have been reported in patients with continuous ambulatory peritoneal dialysis, either alone or in combination with flucytosine. Catheter removal is crucial in these cases.
Warnings For People With Certain Health Conditions
For people with kidney disease: If you have kidney disease or a history of kidney disease, your kidneys may not be able to remove this drug from your body like they should. This may increase the levels of fluconazole in your body and cause more side effects. This drug may also make existing kidney disease worse.
People with liver problems: Fluconazole can cause liver problems. If you already have liver problems, talk with your healthcare professional before taking this drug.
People with high blood sugar levels: The oral suspension form of this drug contains sucrose, a kind of sugar. You shouldnt use this form of the drug if you have a condition that increases your blood sugar level. Talk with your doctor before using this drug if you have high blood sugar levels or a condition, such as diabetes, which can cause high blood sugar levels.
People with abnormal heart rhythms: Using fluconazole can affect your heart rhythm. If you already have an abnormal heart rhythm, taking fluconazole may lead to dangerous heart rhythm problems.
People with certain conditions that lower immunity: If you have certain conditions that lower your immunity, such as cancer, human immunodeficiency virus infection , or acquired immunodeficiency syndrome youre more likely to get a rash from fluconazole. Your doctor will monitor you for a rash and peeling skin.
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What Should I Know About Storage And Disposal Of This Medication
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture . Dispose of any unused liquid medication after 14 days.
It is important to keep all medication out of sight and reach of children as many containers are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location â one that is up and away and out of their sight and reach.
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website for more information if you do not have access to a take-back program.
Other Uses For This Medicine
Fluconazole is also sometimes used to treat serious fungal infections that begin in the lungs and can spread through the body and fungal infections of the eye, skin and nails. Fluconazole is also sometimes used to prevent fungal infections in people who are likely to become infected because they have human immunodeficiency virus or cancer or have had a transplant operation . Talk to your doctor about the possible risks of using this medication for your condition.
This medication may be prescribed for other uses ask your doctor or pharmacist for more information.
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What If I Forget To Take A Dose
If you forget a dose, take it as soon as you remember, unless it’s nearly time for your next dose. In this case, just skip the missed dose and take your next one as normal.
Do not take a double dose to make up for a missed dose.
If you forget doses often, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to remember your medicines.
Diflucan Drug Interactions And Contraindications
Oral Diflucan tablets may interact with other drugs or medications, including vitamins and supplements.
These reactions may affect how well the drug works and cause harm.
Diflucan has relative contraindications with several drugs, including:
Taking Diflucan at the same time as certain medications may not result in serious health complications. Instead, it raises the risk of experiencing side effects associated with the other drug.
These include:
Warfarin: Diflucan may increase the likelihood of bruising, nosebleeds, and blood in urine or stools.
Glyburide and Glipizide: Diflucan may increase the risk of low blood sugar, sweating, chills, and fast pulse.
Theophylline: Diflucan may increase the likelihood of side effects like kidney damage.
Methadone and Fentanyl: Diflucan may increase the risk of drowsiness, confusion, and slower breathing.
Zidovudine: Diflucan may raise ones chances of experiencing headaches, appetite loss, nausea, and vomiting.
Vitamin A: According to one case report, taking Diflucan with all-trans-retinoic acid, an acid form of vitamin A, can potentially cause pseudotumor cerebri or false brain tumors.
These are only some of the many drugs that may cause unwanted interactions with Diflucan.
Therefore, disclosing any current medications or treatments during doctors checkups for this infection is always best.
This will help avoid unnecessary and avoidable harmful effects of the drug.
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What Are Warnings And Precautions For Fluconazole
Warnings
- This medication contains fluconazole. Do not take Diflucan if you are allergic to fluconazole or any ingredients contained in this drug.
- Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately
Contraindications
- This medication contains fluconazole
- Do not take Diflucan if you are allergic to fluconazole or any ingredients contained in this drug
Effects of Drug Abuse
Short-Term Effects
- Syrup contains glycerol may cause headache, stomach upset, and diarrhea
- When driving vehicles or operating machines, it should be taken into account that dizziness or seizures may occasionally occur
- See “What Are Side Effects Associated with Using Fluconazole ?”
Long-Term Effects
- See “What Are Side Effects Associated with Using Fluconazole ?
Cautions
Pregnancy and Lactation
Single maternal oral dose of 150 mg for vaginal candidiasis:
All other indications:
- A few published case reports describe a rare pattern of distinct congenital anomalies in infants exposed in-utero to high dose maternal fluconazole during most or all of the first trimester
- Reported anomalies are similar to those seen in animal studies and consist of brachycephaly, abnormal facies, abnormal calvarial development, cleft palate, femoral bowing, thin ribs and long bones, arthrogryposis, and congenital heart disease
- Fluconazole enters breast milk use caution if breastfeeding